This is a great video from Linda Raynier which explains the tricks to answer this question in detail:
When they ask you to tell me about yourself in an interview, it is critical that you do not talk about your personal and family life but instead focus on your professional background and credentials. Remember to tell a story. Not a life long story, but your professional work story consisting of your work experiences, qualifications and why you are a good fit for this role.
4 major tips that your "tell me about yourself" answer should include:
Tip 1 - Give a snapshot of your work history.
Tip 2 - Make your mini stories achievement-oriented.
Tip 3 - Tell the employer what you KNOW about this role.
Tip 4 - Finally, tell the employer WHY you’re the RIGHT fit for what they need.